Publications - 2012

Leisch, H., Shi, R., Grosse, S., Morley, K., Bergeron, H., Cygler, M., Iwaki, H., Hasegawa, H. and Lau, P. (2012). Cloning, Baeyer-Villiger biooxidations, and structures of the camphor pathway 2-oxo-Δ(3)-4,5,5-trimethylcyclopentenyl-acetyl-coenzyme A monooxygenase of Pseudomonas putida ATCC 17453. Appl Environ. Microbiol., 78, 2200-12.

Kalynych, S., Yao, D., Magee, J., Cygler M. (2012). Structural characterization of closely related o-antigen LPS-chain length regulators. J. Biol. Chem., 287, 15696-705.

Shi, R., Munger, C., Kalan, L., Sulea, T., Wright, G.D. and Cygler, M. (2012). Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold. PNAS, 109, 11824-1182­9.

Kalynych, S., Valvano, M.A. and Cygler, M. (2012). Polysaccharide Co-Polymerases: the Enigmatic Conductors of the O-Antigen Assembly Orchestra. Protein Eng. Des. Sel., 25, 797-802.

Grishin, A.M., Ajamian, E., Zhang, L., Rouiller, I., Bostina, and Cygler, M. (2012). Protein-Protein Interactions in the Β-Oxidation Part of the Phenylacetate Utilization Pathway. Crystal Structure of the PaaF-PaaG Hydratase-Isomerase Complex. J. Biol. Chem., 287, 37986-96.

Du, L., Luo, Y. (2012). Structure of a hexameric form of RadA recombinase from Methanococcus voltae. Acta Cryst. F, 68, 511-16.

Amunugama, R., He, Y., Willcox, S., Forties, R. A., Shim, K. S., Bundschuh, R., Luo, Y., Griffith, J., Fishel, R. (2012). Rad51 Protein ATP Cap Regulates Nucleoprotein Filament Stability, J Biol Chem., 287, 8724-36.

Wisner, A., Desin, T., White, A., Potter A., and Köster, W. (2012). The Salmonella pathogenicity island-1 and -2 encoded type III secretion systems. In: “Salmonella - A diversified Superbug” ed. Y. Kumar, published by InTech, Rijeka, Croatia, pp 469-494 .

Desin, T., Wisner. A., White, A., Potter A., and Köster, W. (2012). The Salmonella Pathogenicity Island encoded Type III Secretion Systems and their Role in Infection of Poultry. In: Salmonella: Classification, genetics and Disease outbreaks; editors:A.S. Monta and P.E.De Santos; Nova Science Publishers, Inc., Hauppauge, NY, USA; pp39-75.

Waldner, L.L., MacKenzie, K.D., Köster, W., and White, A P. (2012). From exit to entry: long-term survival and transmission of Salmonella. Pathogens, 1(2), 128-155.

Meng, S., Zhang, M., Pan,W.,  Li, Z., Anderson, D.H., Ge, B., Wang, C. (2012). Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation.  Int. J. Biochem. Cel.l Biol., 44, 748-758.

Mellor, P., Furber, L.A., Nyarko, J.N.K., Anderson, D.H. (2012) Multiple Roles for the p85a Isoform in the Regulation and Function of PI3K Signalling and Receptor Trafficking. Biochem. J., 441, 23-37.

Alam, M.K., El-Ganiny, A.M., Afroz, S., Sanders, D.A.R., Liu, J.X., Kaminskyj, S.G.W. (2012). Aspergillus nidulans galactofuranose biosynthesis affects antifungal drug sensitivity. Fungal Genetics and Biology 49, 1033-1043

Prusinkiewicz, M.A., Farazkhorasani, F., Dynes, J., Wang, J., Gough, K.M., Kaminskyj, S.G.W. (2012). Proof-of-principle for SERS imaging of Aspergillus nidulans hyphae using in vivo synthesis of gold nanoparticles. Analyst, 137, 4934-42

Abrams, S.R.,  Loewen, M.C., Boyd, J., Cutler, A.J., Gai, Y. Nelson, K.M. (2012). Inhibitors of a 9-cis epoxycarotenoid dioxygenase.United States Patent US 8,283,481 Issues Oct 9, 2012.

Love R.P., Xu H., Chelico L. (2012). Biochemical Analysis of Hypermutation by the Deoxycytidine Deaminase APOBEC3A. J. Biol. Chem. 287, 30812-30822.

Senavirathne G, Jaszczur M, Auerbach PA, Upton TG, Chelico L, Goodman MF, Rueda D. (2012). Single-stranded DNA Scanning and Deamination by APOBEC3G Cytidine Deaminase at Single Molecule Resolution. J. Biol. Chem., 287, 15826-15835.

Umeshappa C.S., Nanjundappa R.H., Xie Y., Freywald A., Xu Q., Xiang J. (2012). Differential requirements of CD4(+) T cell signals for effector CTL priming and functional memory CTL development at higher CD8(+) T cell precursor frequency. Immunology [Epub ahead of print]. Funded by CIHR.

Umeshappa C. S., Nanjundappa R. H., Xie Y., Freywald A., Deng Y., Ma H., Xiang J. (2012). CD154 and IL-2 Signaling of CD4(+) T Cells Play a Critical Role in Multiple Phases of CD8(+) CTL Responses Following Adenovirus Vaccination. PLoS One 7(10). Funded by CIHR

Munegowda M., Xu S., Freywald A., Xiang J. (2012). CD4(+) Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene. Mol Immunol 51, 143-9. Funded by CIHR.

Mousseau, D.D. and Baker G.B. (2012). Recent developments in the regulation of monoamine oxidase form and function: is the current model restricting our understanding of the breadth of contribution of monoamine oxidase to brain [dys]function? In: Current Topics in Medicinal Chemistry on "Monoamine Oxidase as a Target in Medicinal Chemistry and Drug Discovery". 12:2163-2176.

Baker G.B., Matveychuk D., MacKenzie E.M., Dursun S.M. and Mousseau D.D. (2012). Monoamine oxidase inhibitors and neuroprotective mechanisms. Bull. Clin. Psychopharmacol. 22: 293-296.

Wei Z., Satram-Maharaj T., Chaharyn B., Kuski K., Pennington P.R., Cao X., Chlan J., and Mousseau D.D. (2012). Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation. J. Neural Transm. 119: 1285-1289.

Meng X., D'Arcy C., Morgan D., and Mousseau D.D. (2012). Predicting the Risk of Dementia Among Canadian Seniors: A Useable Practice-friendly Diagnostic Algorithm. Alzheimer Dis. Assoc. Disord. 27: 23-29.

Wei Z., Gabriel G.G., Rui L., Cao X., Pennington P.R., Chlan-Fourney J., Nazarali A.J., Baker G.B. and Mousseau D.D. (2012). Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex. J. Alz. Dis. 28: 403-422.

Meng X., D’Arcy C., Tempier R., Kou C., Morgan D. and Mousseau D.D. (2012). Survival of patients with incident dementia who had a pre-existing psychiatric disorder: A population population-based 7-year follow-up study. Internat. J. Geriat. Psychiatry 27: 683-691.

.Alam, K., El-Ganiny, A.M., Afroz, S., Sanders, D.A.R., Liu, J., Kaminskyj, S.G.W. (2012). Aspergillus nidulans Galactofuranose biosynthesis affects antifungal drug sensitivity. Fung. Gen. Biol. 49:1033-43

van Straaten, K.E., Routier, F.H. and Sanders, D.A.R. (2012). Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus . J. Biol. Chem. 287: 10780-10790.

van Straaten, K.E., Routier, F.H. and Sanders, D.A.R. (2012). Towards the Crystal Structure Elucidation of Eukaryotic UDP-galactopyranose Mutase. Acta Cryst. F. 68: 455-459.

Cotelesage, JH., Grochulski, P., Pickering, IJ., George, GN., Fodje, M. (2012). Journal of Synchrotron Radiation, 19, 997-891

Cotelesage, JH., Pushiea, MJ., Grochulski, P., Pickering, IJ., George, GN. (2012). Metalloprotein active site structure determination: Synergy between X-ray absorption spectroscopy and X-ray crystallography. Journal of Inorganic Biochemistry 115, 127-1377

Grochulski, P., Fodje, M, Labiuk, S. et al. (2012). Canadian macromolecular crystallography facility: a suite of fully automated beamlines, Journal of Structural and Functional Genomics, 13(2), 49-55

Grochulski P., Fodje M. N., George G. (2012). Status and Vision for Structural Biology at the Canadian Light Source Acta Physica Polonica A, 121, 866-870

Fodje, M., Janzen, J., Berg, J., Black, G., Labiuk, S., Gorin, J. and Grochulski, P. (2012). MxDC and MxLIVE:  Software for data-acquisition, information management and remote access to macromolecular crystallography J. Synchrotron Rad. 19, 274-280

Schatte G, Labiuk S, Li B, Burnett PG, Reaney M, Grochulski P, Fodje M, Yang J, Sammynaiken R.(2012). Cyclo-linopeptide B methanol tris-olvate Acta Cryst. E 68:o50-51

Omid Tavassoly and Jeremy S. Lee, (2012). Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.  FEBS Lett., 586, 3222-3228

Besnik Krasniqi, Erin Scruten, Jaret Pill, Jeremy S. Lee and Scott Napper, (2012). Stability, toxicity and biological activity of retro, inversed and retro-inversed glucagon isomers. J. Pept. Sci. 18, 519-516

Besnik Krasniqi and Jeremy S. Lee, (2012).  The importance of adding EDTA for the nanopore analysis of proteins.  Metallomics, 4, 539-544.

Claudia Madampage, Omid Tavassoly, Chris Christensen, Meena Kumari and Jeremy S. Lee, (2012).  Nanopore analysis: An emerging technique for studying the folding and misfolding of proteins.  Prion, 6, 1-9.

Radu I. Stefureac, Anton Kachayev and Jeremy S. Lee, (2012).  Modulation of the translocation of peptides through nanopores by the application of an AC electric field.  Chem. Commun., 48, 1928-1930

Asare, E.K., Båga, M., Rossnagel, B.G. and Chibbar, R.N. (2012). Polymorphism in the barley granule bound starch synthase I (Gbss1) gene associated with grain starch variant amylose concentration.  J. Agric. Food Chem. 60: 10082-10092

Sobti, N., Juneja, S.K., Yadav, P.K., Chibbar, R.N. and Behl, R.K. (2012). Vermicompost Application for Improving Grain Yield and Quality in Cereals- Harnessing Metagenomics and Induced Gene Expression Changes. Annals of Biology 28 (2):73-77.

Chibbar, R.N. and Dass, S. (2012). Crop improvement for enhanced grain quality and utilization. Quality Assurance and Safety of Crops & Foods 4(3): 116 – 118

Titorenko, V.I., and Harkness, T.A.A. (2012). The spatiotemporal dynamics of longevity-defining cellularprocesses and its modulation by genetic, dietary, and pharmacological anti-aging interventions. Frontiers in Integrated Physiology 3:419

Postnikoff, S.D.L. and Harkness, T.A.A. (2012). Mechanistic insights into aging, cell-cycle progression, and stress response. Frontiers in Integrated Physiology 3: 183

Postnikoff, S.D., Malo, M.E., Wong, B., and Harkness, T.A.A. (2012). The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. PLoS Genetics 8:e1002583.

Li, L., Wang, J., Hou, J., Wu, Z., Zhuang, Y., Lu, M., Zhang, Y., Zhou, X., Li, Z., Xiao, W., and Zhang, W. (2012). Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm. FEBS Lett. 586: 4100-4107

Zang, Y., Wang, Q., Xue, C., Li, M., Wen, R. and Xiao, W. (2012). Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage. Rice 5: 24

Wen, R., Li, J., Xu, X., Cui, Z. and Xiao, W. (2012). Zebrafish Mms2 promotes K63-linked polyubiquitination and is involved in p53-mediated DNA-damage response. DNA Repair 11: 157-166

Biss, M. and Xiao, W. (2012). Selective tumor killing based on specific DNA-damage response deficiencies. Cancer Biol. & Ther. 13: 239-246

Hasan NM, Gupta A, Polishchuk E, Yu CH, Polishchuk R, Dmitriev OY, Lutsenko S. (2012). Molecular events initiating exit of a copper-transporting ATPase ATP7B from the trans-Golgi network. J Biol Chem. 287, 36041-36050.

O'Grady C, Rempel BL, Sokaribo A, Nokhrin S, Dmitriev OY. (2012). One-step amino acid selective isotope labeling of proteins in prototrophic Escherichia coli strains. Anal Biochem. 426, 126-128.

Uhlemann EM, Pierson HE, Fillingame RH, Dmitriev OY. (2012). Cell-free synthesis of membrane subunits of ATP synthase in phospholipid bicelles: NMR shows subunit a fold similar to the protein in the cell membrane. Protein Sci. 21, 279-288.

Barreto K, Aparicio A, Bharathikumar VM, DeCoteau JF, Geyer CR. (2012). Yeast two-hybrid screening of cyclic peptide libraries using a combination of random and PI-deconvolution pooling strategies. Protein Eng Des Sel. 25, 453-464.

Geyer CR, McCafferty J, Dübel S, Bradbury AR, Sidhu SS. (2012). Recombinant antibodies and in vitro selection technologies. Methods Mol Biol. 901, 11-32.

Charavaryamath, C., Gonzalez-Cano, P., Fries, P., Gomis, S., Doig, K., Scruten, E., Potter, A., Napper S. and Griebel, P.  (2012) Host Responses to Persistent Mycobacterium avium subspecies paratuberculosis infection in surgically isolated bovine ileal segments. Clinical and Vaccine Immunology 20:156-165 Impact Factor 2.6

 Hedlin, P., Taschuk, R., Potter, A., Griebel, P. and Napper S. (2012) Detection and Control of Prion Diseases in Food Animals. ISRN Veterinary Sciences. Vol 2012, Article ID 254739 Impact Factor 3.0

Arsenault,  R.A. Yue L., Maattanen, P., Scruten, S., Doig, K., Potter, A., Philip Griebel, P., Kusalik, A. and Napper, S. (2012) Altered Toll-Like Receptor 9 Signaling in Mycobacterium avium subsp. paratuberculosis Infected Bovine Monocytes Reveals Potential Therapeutic Targets. Infection and Immunity 81:226-237 Impact Factor 4.2

Arsenault, R. A., Yue, L., Potter, A., Griebel, P., Kusalik, A. and Napper, S. (2012) Induction of Ligand-Specific PrpC signalling in Human Neuronal Cells. Prion 7:1 Factor 2.85

Bodnarchuk, T., Napper, S., Rapin, N. and Misra, V. (2012) Zhangfei induces cell death in ONS-76 medulloblastoma cells by stimulating an autocrine TrkA/NGF signaling pathway. 109:485-501 Impact Factor 5.7

Arsenault, R. J., Li, Y., Bell, K., Doig, K., Potter, A., Griebel, P., Kusalik, A. and Napper, S. (2012) Inhibition of Interferon Gamma Induced Signaling by Mycobacterium avium subsp. paratuberculosis. Accepted by Infection and Immunity June 6, 2012 Impact Factor 4.1

Krasniqi, B., Scruten, E., Pillar, J., Lee, J and Napper, S. (2012) Stability, Toxicity and Biological Activity of Retro, Inversed and Retro-Inversed Glucagon Isomers. Accepted by The Journal of Peptide Science. June 2, 2012 Impact Factor 1.8

 Li, Y., Arsenault, R. J., Trost, B., Slind, J., Griebel, P. J., Napper, S. and Kusalik, A (2012) A Systematic Approach for Analysis of Peptide Array Data. Science Signaling epub ahead of print April 19, 2012 Impact Factor 7.5

Wu, Y. (2012). Unwinding and rewinding: Double faces of helicase? Journal of Nucleic Acids. In press (PMID: 22888405).

Xie, J., Peng, M., Guillmette, S., Venkatesh, A., Wu, Y., Brosh, R., and Cantor, S.B. (2012). FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA Damage Response. PLoS Genetics. 8(7):e1002786.

Wu, Y., Sommers,J.A., Loiland,J., Kitao,H., Kuper,J., Kisker,C., and Brosh,R.M.Jr. (2012). The Q Motif of FANCJ DNA Helicase Regulates its Dimerization, DNA Binding, and DNA Repair Function. J Biol Chem. 287: 21699-21716.

Suhasini, A., Sommers, JA., Yu, S., Wu, Y., Xu, T., Kelman, Z., Kaplan, DL., and Brosh, RM.,Jr. (2012). DNA repair and replication fork helicases are differentially affected by an alkylphosphotriester lesion. J Biol Chem. 287:19188-19198.

Wu, Y., and Brosh,R.M.,Jr. (2012). DNA Helicase and Helicase-Nuclease Enzymes with a Conserved Iron-Sulfur Cluster. Nucleic Acids Res. 40:4247-4260.

Yang, J., Wang,Q., Zheng,W., Tuli,J., Li,Q., Wu,Y., Hussein,S., Dai,XQ., Shafiei,S., Li,XG., Shen,PY., Tu,JC., Chen,XZ.  (2012). Receptor for activated C kinase 1 (RACK1) inhibits the function of TRP-type channel Pkd2L1 through physical interaction. J Biol Chem. 287: 6551-6561.

Wu, Y., Sommers,J., Khan,I., de Winter,J., and Brosh,R. (2012). Biochemical characterization of Warsaw Breakage Syndrome helicase. J Biol Chem. 287:1007-1021.

Izadifar M, Alcorn J. (2012) Mass transfer modeling of hepatic drug elimination using local volume averaging approach. Frontiers in Heat and Mass Transfer, DOI: 10.5098/hmt.v3.3.3005.

 Ling BB, Wright J, Buker K, Alcorn J, Zello G, Lohmann K (2013). The Effects of Pre-analytical Processing and Storage on Bovine Blood D- and L-Lactate Concentrations. Open Vet Sci J 6:23-29.

 Billinsky J, Maloney K, Krol E, Alcorn J (2012). A comparison between lignans from creosote bush and flaxseed and their potential to inhibit cytochrome P450 enzyme activity. Drug Discovery Research in Pharmacognosy, Omboon Vallisuta and Suleiman M. Olimat (Ed.), ISBN: 978-953-51-0213-7, InTech, Available from:

Abeysekara S, Zello GA, Lohmann KL, Alcorn J, Hamilton DL, Naylor JM (2012). Infusion of sodium bicarbonate in experimentally induced metabolic acidosis does not provoke cerebrospinal fluid (CSF) acidosis in calves. Canadian Journal of Veterinary Research 76(1): 16-22.

Ling BB, Aziz C, Alcorn J (2012). Systematic Evaluation of Key L-Carnitine Homeostasis Mechanisms during Postnatal Development in Rat. Nutrition and Metabolism Journal 9(1):66

Chen J, Woodbury MR, Alcorn J, Honaramooz A (2012). Dietary supplementation of female rats with elk velvet antler improves physical and neurological development of offspring. Evidence-Based Complementary and Alternative Medicine 2012:640680.

Viveky N, Toffelmire L, Thorpe L, Billinsky J, Alcorn J, Hadjistavropoulos T, Whiting SJ (2012). Use of vitamin and mineral supplements in long-term care home residents. Applied Physiology, Nutrition, and Metabolism 37:100-105.

 Ling BB, Peng F, Alcorn J, Lohmann K, Bandy B, Zello G (2012). D-Lactate Altered Mitochondrial Energy Production in Rat Brain and Heart but not Liver. Nutrition and Metabolism 9(1):6.